Scientific publications NEWTBVAC
Publications 2012
A Human Challenge Model for Mycobacterium tuberculosis Using Mycobacterium bovis Bacille Calmette-Guérin
Journal of Infectious Diseases, Volume 205, Issue 7, Pp. 1035-1042.
Angela M. Minassian, Iman Satti, Ian D. Poulton, Joel Meyer, Adrian V. S. Hill and Helen McShane
A New Challenge for the Tuberculosis Vaccine Community?
The Journal of Infectious Diseases, Volume 205, Issue 7, Pp. 1029-1031
Hazel M. Dockrell
Phagosomal Rupture by Mycobacterium tuberculosis Results in Toxicity and Host Cell Death
PLoS Pathog 8(2): e1002507. doi:10.1371/journal.ppat.1002507
Roxane Simeone, Alexandre Bobard, Juliane Lippmann, Wilbert Bitter, Laleh Majlessi, Roland Brosch, Jost Enninga
Activation of the NLRP3 inflammasome by Mycobacterium tuberculosis is uncoupled from susceptibility to active tuberculosis.
European Journal of Immunology 2012. 42: 374–384
Dorhoi A, Nouailles G, Jörg S, Hagens K, Heinemann E, Pradl L, Oberbeck-Müller D, Duque-Correa MA, Reece ST, Ruland J, Brosch R, Tschopp J, Gross O, Kaufmann SH.
Protective immunity afforded by attenuated, PhoP-deficient Mycobacterium tuberculosis is associated with sustained generation of CD4(+) T-cell memory.
Eur J Immunol. 2012 Feb;42(2):385-92
Nambiar JK, Pinto R, Aguilo JI, Takatsu K, Martin C, Britton WJ, Triccas JA.
Potential of Mycobacterium tuberculosis resuscitation-promoting factors as antigens in novel tuberculosis sub-unit vaccines.Microbes Infect. 2012 Jan;14(1):86-95. Epub 2011 Aug 31
Romano M, Aryan E, Korf H, Bruffaerts N, Franken CL, Ottenhoff TH, Huygen K.
Publications 2011
Identification of biomarkers for tuberculosis disease using a novel dual-color RT-MLPA assay.
Genes Immun. 2012 Jan;13(1):71-82. doi: 10.1038/gene.2011.64. Epub 2011 Sep 29.
Joosten SA, Goeman JJ, Sutherland JS, Opmeer L, de Boer KG, Jacobsen M, Kaufmann SH, Finos L, Magis-Escurra C, Ota MO, Ottenhoff TH, Haks MC.
Pegylation of DDA:TDB liposomal adjuvants reduces the vaccine depot effect and alters the Th1/Th2 immune responses.
J Control Release. 2011 Oct 18
Kaur R, Bramwell VW, Kirby DJ, Perrie Y.
Relief from Zmp1-mediated arrest of phagosome maturation is associated with facilitated presentation and enhanced immunogenicity of mycobacterial antigens.
Clinical and Vaccine Immunology June 2011 vol. 18 no. 6 907-913
Pål Johansen, Antonia Fettelsschoss, Beat Amstutz, Petra Selchow, Ying Waeckerle-Men, Peter Keller, Vojo Deretic, Leonhard Held, Thomas M. Kündig, Erik C. Böttger, and Peter Sander
Identification of human T-cell responses to Mycobacterium tuberculosis resuscitation promoting factors in long-term latently infected individuals.
Clinical and Vaccine Immunology 2011 Jan 19.
Commandeur S, van Meijgaarden KE, Lin MY, Franken KL, Friggen AH, Drijfhout JW, Oftung F, Korsvold GE, Geluk A, Ottenhoff TH.
A multistage tuberculosis vaccine that confers efficient protection before and after exposure.
Nature Medicine 2011 Feb;17(2):189-94
Aagaard C, Hoang T, Dietrich J, Cardona PJ, Izzo A, Dolganov G, Schoolnik GK, Cassidy JP, Billeskov R, Andersen P.
Comparison of the Depot Effect and Immunogenicity of Liposomes Based on Dimethyldioctadecylammonium (DDA), 3β-[N-(N′,N′-Dimethylaminoethane)carbomyl] Cholesterol (DC-Chol), and 1,2-Dioleoyl-3-trimethylammonium Propane (DOTAP): Prolonged Liposome Retention Mediates Stronger Th1 Responses
Molecular Pharmaceutics, 2011, 8 (1), pp 153–161
Henriksen-Lacey M, Christensen D, Bramwell VW, Lindenstrøm T, Agger EM, Andersen P, Perrie Y.
Publications 2010
First in humans: A new molecularly defined vaccine shows excellent safety and strong induction of long-lived Mycobacterium tuberculosis-specific Th1-cell like responses.
Human Vaccines 2010 Dec 1;6(12).
Ottenhoff TH, Doherty TM, Dissel JT, Bang P, Lingnau K, Kromann I, Andersen P.
Interactions of Attenuated Mycobacterium tuberculosis phoP Mutant with Human Macrophages
PLoS ONE 5(9): e12978
Ferrer NL, Gomez AB, Neyrolles O, Gicquel B, Martin C
High Content Phenotypic Cell-Based Visual Screen Identifies Mycobacterium tuberculosis Acyltrehalose-Containing Glycolipids Involved in Phagosome Remodeling
PLoS Pathog 6(9): e1001100
Brodin P, Poquet Y, Levillain F, Peguillet I, Larrouy-Maumus G, et al.
Immunogenicity and protection induced by a Mycobacterium tuberculosis sigE mutant in a BALB/c mouse model of progressive pulmonary tuberculosis.
Infect Immun. 2010 Jul;78(7):3168-76.
Hernandez Pando R, Aguilar LD, Smith I, Manganelli R.
Radiolabelling of Antigen and Liposomes for Vaccine Biodistribution Studies.
Pharmaceutics, 2, 91-104.
Malou Henriksen-Lacey, Vincent W. Bramwell and Yvonne Perrie (2010).